Memory enhancing-R-N-(1-azabicyclo[2.2.2.]oct-3-yl)benzamides and thiobenzamides
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United States of America Patent
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May 21, 1991
Grant Date -
N/A
app pub date -
Aug 3, 1989
filing date -
Aug 4, 1988
priority date (Note) -
Expired
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Abstract
Compounds of general formula I ##STR1## wherein: X represents oxygen or sulphur; each of R.sup.1 and R.sup.3 independently represents hydrogen or a C.sub.1 -C.sub.4 alkyl group; Ar represents: a phenyl ring optionally substituted by one, two or three C.sub.1 -C.sub.4 alkoxy groups and/or by one or two halogen atoms; a phenyl ring of the general formula ##STR2## wherein R.sup.2 represents halogen, 4,5-benzo, C.sub.1 -C.sub.8 alkoxy, C.sub.1 -C.sub.4 alkylcarbonyl or Am, wherein Am represents amino, methylamino or dimethylamino, R.sup.4 represents C.sub.1 -C.sub.8 alkyl, n is 1 or 2; or a pyrimidinyl moiety of the general formula ##STR3## wherein R.sup.5 is C.sub.1 -C.sub.4 alkyl; and their N-oxides and pharmaceutically acceptable salts are useful as memory- and/or learning-enhancing agents. A preferred compound is R-(+)-4-amino-N-(1-azabicyclo[2.2.2]oct-3-yl)-5-chloro-2-methoxybenzamide.
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