Importance

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Abstract

Therapeutically useful isoquinolinone derivatives of the formula A--X--R.sup.3, wherein A represents a group of the formula: ##STR1## wherein R.sup.1 and R.sup.2 represents cycloalkyl, alkyl, alkenyl or alkynyl optionally substituted by halogen or cycloalkyl, or represents optionally substituted aryl or heteroaryl, R.sup.4 represents hydrogen, halogen, optionally substituted alkyl, alkenyl or alkynyl, optionally substituted aryl or heteroaryl, or a group R.sup.6 O-- wherein R.sup.6 represents alkyl, aryl or arylalkyl, X represents ethylene or vinylene, R.sup.3 represents a group of the formula: --Y.sup.1 --CH.sub.2 --CH(OH)--CH.sub.2 --COOR.sup.5 wherein Y.sup.1 represents carbonyl, hydroxymethylene or --C(OR).sub.2 --wherein R represents alkyl or the two R symbols together represent alkylene and R.sup.5 represents hydrogen or optionally substituted alkyl or R.sup.3 represents a lactol or lactone ring, and pharmaceutically acceptable salts thereof, processes for their preparation and compositions containing them are described.

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First Claim