1,4-dihydropyridine enantiomers
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United States of America Patent
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Feb 19, 1991
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N/A
app pub date -
Sep 19, 1989
filing date -
Mar 27, 1987
priority date (Note) -
Expired
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Abstract
Enantiomerically-pure dihydropyridines of formula I ##STR1## are effective vasodilators useful for treating coronary diseases. They have particularly advantageous properties with regard to extent and controllability of blood pressure lowering, a surprisingly small (and for repeated administration--vanishing) increase in heart rate, excellent bioavailability, high therapeutic index, lack of central side effects, lack of kinetic interactions with other substances, absence of tolerance development, well-balanced physical properties and high stability. A new process for preparing these compounds is also presented.
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