Derivatives of monophosphoryl lipid A
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United States of America Patent
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Jan 22, 1991
Issued Date -
N/A
app pub date -
Oct 22, 1987
filing date -
Aug 26, 1983
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Expired
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Abstract
Novel derivatives of monophosphoryl lipid A and a process for their preparation are provided. The derivatives contain one or more free groups, such as an amine, on a side chain attached to the primary hydroxyl groups of the monophosphoryl lipid A nucleus through an ester group. The derivatives provide a convenient method for coupling the lipid A through coupling agents to various biologically active materials, substrates, and the like, wherein the immunostimulant properties of lipid A are desired.
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