Process for the controlled preparation of low molecular weight glucosaminoglycans
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United States of America Patent
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Jan 22, 1991
Grant Date -
N/A
app pub date -
Nov 16, 1987
filing date -
Nov 24, 1986
priority date (Note) -
Expired
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Abstract
A process for the controlled preparation of low molecular weight glucosaminoglycans by treating conventional high molecular weight glucosaminoglycans in the solid state or in solution form with a rectilinear gamma ray beam at doses within the range of 2.5 to 20 Mrad supplied by successive irradiation stages with cooling intervals between one irradiation stage and the next in the dynamic phase. The mixture obtained is subjected to fractionation, purification, neutralization and lyophilization. The glucosaminoglycans obtained have a molecular weight of between 1000 and 35,000 daltons and are used for the preparation of pharmaceutical compositions possessing antithrombotic, fibinolytic, antiatherogenic and heparin cofactor II activation activity.
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