Process for obtaining chemically defined and reproducible polydeoxyribonucleotides
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United States of America Patent
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Jan 15, 1991
Issued Date -
N/A
app pub date -
Jul 5, 1989
filing date -
Apr 17, 1986
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Expired
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Abstract
By carrying out the depolymerization of stabilized solutions of highly polymerized and nicked polydeoxyribonucleotides, as obtained through stabilizing aggregation of raw nucleic acids, the depolymerization being carried out by heating at controlled temperature and being controlled as a function of the variation of the reversible hyperchromicity, followed by the removal of the hydrogen bonds in the double stranded filaments and by thermal stabilization of the single stranded filaments, the polydeoxyribonucleotide, known as Defibrotide is obtained. Defibrotide has the following formula of random sequence: P.sub.1-5,(dAp).sub.12-24,(dGp).sub.10-20, (dTp).sub.13-26,(dCP).sub.10-20, wherein P=phosphoric radical dAp=deoxyadenylic monomer dGp=deoxyguanylic monomer dTp=deoxythymidylic monomer dCp=deoxycytidylic monomer and has well defined chemico-physical properties, reproducible in the industrial production.
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