Biological and chemical method for hydroxylating 4-substituted biphenyls and products obtained therefrom
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United States of America Patent
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Jan 1, 1991
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N/A
app pub date -
Dec 20, 1989
filing date -
Dec 20, 1989
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Expired
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Abstract
A method is provided for converting 4-substituted biphenyls, such as 4-hydroxybiphenyl, to the corresponding 3,4'-dihydroxybiphenyl utilizing mutant strains of Alcaligenes eutrophus or Pseudomonas putida. Hydroxylation of the unsubstituted biphenyl ring to the corresponding (1S-cis)-3-(4-hydroxyphenyl)-3,5-cyclohexadiene-1,2-diol and its conversion to the corresponding triacetate, followed by treatment in base to form 3,4'-dihydroxybiphenyl is also provided.
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