Novel 1.alpha.-hydroxyvitamin D.sub.2 epimer and derivatives
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United States of America Patent
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Nov 27, 1990
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N/A
app pub date -
Mar 9, 1989
filing date -
Mar 9, 1989
priority date (Note) -
Expired
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Abstract
The invention provides a new vitamin D.sub.2 compound, 1.alpha.-hydroxy-24-epi-vitamin D.sub.2 and certain hydroxy-protected derivatives thereof. The new compound exhibits a distinctive activity pattern comprising high potency in stimulating intestinal calcium transport and little or no activity in inducing bone calcium mobilization or the differentiation of undifferentiated cells in culture, thereby evincing utility in the treatment of diseases characterized by loss of bone mass.
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