Microcrystals comprising an active substance having an affinity for phospholipids, and at least one phospholipid, process of preparation
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United States of America Patent
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Nov 27, 1990
Issued Date -
N/A
app pub date -
Jun 8, 1989
filing date -
Dec 5, 1986
priority date (Note) -
Expired
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Abstract
The present invention relates to microcrystals of a substance, which substance is insoluble in water and has an affinity for phospholipids, as well as a process for its preparation. According to the invention, one or more organic solvents are evaporated from a solution of phospholipids and substance, and the film obtained thereby, after evaporation of the one or more solvents, is suspended in an aqueous solution by vigorous stirring. The invention also relates to pharmaceutical compositions containing as active principle these microcrystals, particularly liquid pharmaceutical compositions packaged in injectable form or in sprayable form.
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