Non-ionic polyol contrast media from ionic contrast media
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United States of America Patent
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Sep 4, 1990
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app pub date -
Jul 1, 1988
filing date -
Aug 9, 1985
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Abstract
Novel non-ionic contrast media of a hitherto unknown combination of low osmolality and low viscosity are efficiently prepared from generally available ionic contrast media or non-iodinated precursors. Particularly, polyhydroxyhalo-hydrocarbons are employed with a triiodo-substituted acylamido benzoic acids in aqueous weakly basic media to selectively substitute the amido nitrogen, followed by activation of the carboxyl group for amide formation.
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