Salt of diclofenac with a pyrrolidine compound and pharmaceutical compositions which contain it
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United States of America Patent
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Aug 14, 1990
Grant Date -
N/A
app pub date -
Nov 9, 1987
filing date -
Nov 13, 1986
priority date (Note) -
Expired
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Abstract
The salt of diclofenac with a cyclic organic base is prepared by dissolving diclofenac in a suitable organic solvent, adding said cyclic organic base, reacting the two components together, removing the solvent and crystallizing the product obtained. Said salt is water soluble to an extent from 20% w/v to an extent exceeding 50% w/v, and is used to prepared pharmaceutical compositions preferably in granular form for use by dissolving in water for oral administration.
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