Method of treating pruritus with nalmefene and clonidine
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United States of America Patent
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Aug 7, 1990
Issued Date -
N/A
app pub date -
Feb 21, 1989
filing date -
Oct 29, 1985
priority date (Note) -
Expired
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Abstract
A method of treating a mammal suffering from pruritus, whether antigen-induced or disease-induced, comprising orally administering to the subject from about 1 to about 25 mg of the narcotic antagonist nalmefene for an initial period of 1 to 7 days, and gradually increasing the dosage level of nalmefene by increments of 1 to 25 mg per day during successive periods of 1 to 7 days to a maximum of 150 mg per day. Clonidine or clonidine hydrochloride may be administered concomitantly with the nalmefene to alleviate opioid withdrawal symptoms.
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