Azaindole derivatives useful as cholesterol biosynthesis inhibitors
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United States of America Patent
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Jul 3, 1990
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N/A
app pub date -
Mar 8, 1989
filing date -
Sep 10, 1986
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Expired
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Abstract
Compounds of the formula I: ##STR1## wherein X is the residue of an unsubstituted 6-membered aromatic ring having 3 carbon atoms and one nitrogen atom; R.sup.1 is C.sub.1-6 primary alkyl (free of asymmetric carbon atoms), or isopropyl; R.sup.2 is substituted or unsubstituted phenyl, primary or secondary C.sub.1-6 alkyl (free of asymmetric carbons), C.sub.3-6 cycloalkyl or phenalkyl as defined in the Specification ##STR2## in which R.sup.8 is hydrogen, R.sup.9 or M, wherein R.sup.9 is a physiologically acceptable and hydrolyzable ester group, and M is a pharmaceutically acceptable cation; are obtained by multi-step processes and are useful as cholesterol biosynthesis inhibitors. 3
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