Anxiolytic N-substituted benzamides
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United States of America Patent
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Jun 26, 1990
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N/A
app pub date -
Dec 4, 1989
filing date -
Aug 3, 1987
priority date (Note) -
Expired
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Abstract
A method of treating anxiety including administering to a person to be treated an effective amount of compounds of the general formula: ##STR1## wherein the various substituents are defined hereinbelow have pharmacological properties rendering them useful as antiemetic agents with reduced undesirable side-effects or as anxiolytic agents. Various methods are described for their preparation involving formation of the amide link, etherification of the 2-hydroxy derivative, introducing the R.sup.5 CH.sub.2 group on the N-unsubstituted azabicyclooctane or nonane or, for 4-amino compounds, by hydrolysing a 4-acylamino derivative.
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