Pyrroloisoquinolines useful as hypercholesterolemic and hyperlipoprotienimic agents

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United States of America Patent

PATENT NO 4933350
SERIAL NO

07230038

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Abstract

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Pyrrolo[2,1-a]isoquinoline derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 each represent cycloalkyl or alkyl, alkenyl or alkynyl which may be halogen-substituted, or optionally substituted aryl or heteroaryl, X represents ethylene or vinylene, R.sup.3 represents a group of the formula: --Y--CH.sub.2 --CH(OH)--CH.sub.2 --COOR.sup.5 II wherein Y represents carbonyl or hydroxymethylene and R.sup.5 represents hydrogen or optionally substituted alkyl, or R.sup.3 represents a lactone ring, and the symbols R.sup.4 represent hydrogen, halogen, optionally substituted alkyl, alkenyl or alkynyl, optionally substituted aryl or heteroaryl, or a group of the formula R.sup.6 O--, wherein R.sup.6 represents alkyl, aryl or arylalkyl and pharmaceutical properties.

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Patent Owner(s)

Patent OwnerAddress
RHONE-POULENC RORER LTDRPR HOUSE 52 ST LEONARD'S ROAD EASTBOURNE EAST SUSSEX BN21 3YG

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ashton, Michael J Chelmsford, GB2 5 17
Dron, Donald I Upminster, GB2 3 9
Fenton, Garry Brentwood, GB2 36 326
Lythgoe, David J Gidea Park, GB2 6 16
Newton, Christopher G Chelmsford, GB2 8 22
Riddell, David Billericay, GB2 5 30

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