Latent isocynate derivatives useful for deactivating enzymes
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United States of America Patent
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May 29, 1990
Issued Date -
N/A
app pub date -
Nov 6, 1987
filing date -
Jul 18, 1985
priority date (Note) -
Expired
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Abstract
Certain amino-acid derivatives are disclosed as effective inhibitors of human leukocyte elastase and therefore useful in preventing the imbalance of this proteolytic enzyme in vivo. The compounds specifically are derivatives L-valine, L-norvaline, L-norleucine, and L-methionine methyl ester azolides succinimides or pyridones and sulfonate salts, and related compounds such as L-leucine and L-phenylalanine methyl ester derivatives. The compounds were found to be excellent inhibitors in that they embody both inhibitory and anti-oxidant or anti-inflammatory activity.
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