Purification of hemoglobin and modified hemoglobin by affinity chromatography
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United States of America Patent
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May 15, 1990
Grant Date -
N/A
app pub date -
Mar 14, 1986
filing date -
Jun 26, 1985
priority date (Note) -
Expired
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Abstract
The invention disclosed relates to a method for the purification of hemoglobin by the technique of affinity chromatography. Contrary to current belief, the binding of oxygen and selected polyanions to hemoglobin is not mutually exclusive. The novel method comprises immobilizing a polyanion which specicically binds hemoglobin via its polyanion binding site, on a chromatographic gel and passing the hemoglobin containing solution or mixture through the gel. The hemoglobin is thus retained in the gel, while impurities are eluted from the gel. The novel method is also applicable to the separation of unmodified hemoglobin from a liquid reaction mixture containing modified and unmodified hemoglobin.
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