Arg-Serpin human plasminogen activator inhibitor designated PAI-2
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United States of America Patent
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May 8, 1990
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Feb 6, 1987
filing date -
May 18, 1984
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Abstract
The invention is directed to an Arg-Serpin human plasminogen activator inhibitor designated PAI-2. This protein is prepared via recombinant DNA means. The invention also includes other serpins which can be made by amino acid substitutions or deletions in conserved regions of PAI-1 and PAI-2, as shown in FIG. 4. The proteins of the invention can be used to inhibit, or at least modulate, human plasminogen activator activity in a variety of physiological conditions, e.g., fibrinolysis, tumor metastasis, and tumor growth.
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