Glycero-3(2)-phospho-L-serine derivatives and salts thereof

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United States of America Patent

PATENT NO 4916249
SERIAL NO

07376161

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Abstract

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The invention relates to novel glycero-3(2)phospho-L-serine derivatives of the general formula ##STR1## in which A represents unsubstituted or substituted (C5-C30) alkoxy, or unsubstituted or substituted (C5-C30) alkenoxy, whereby a double bond of the alkenoxy residue does not originate at the C atom bound to oxygen, or halogen, or a group of the general formula --O--(CH.sub.2).sub.n --CF.sub.3 II, wherein n is 0 or an integer 1, 2 or 3, one of the two residues B and C, which is identical to or different from A, has one of the definitions given for A or represents hydrogen, and the respective other residue represents the phosphatidyl-Lserine group of the formula ##STR2## with the proviso that at least one residue A, B or C represents (C5-C30) alkoxy or (C5-C30) alkenoxy; and the pharmaceutically acceptable salts of compounds of general formula I with bases, a process for the preparation thereof, pharmaceutical preparations containing the said compounds, and their use in drugs with cytostatic activity.

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Patent Owner(s)

Patent OwnerAddress
CLARION PHARMACEUTICALS INC565 SCIENCE DRIVE MADISON WI 53711

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Brachwitz, Hans c/o Academy of Sciences, Otto-Nuschke-Strasse 22/23, D-x 1086 Berlin, DD 2 14
Fichtner, Iduna c/o Academy of Sciences, Otto-Nuschke-Strasse 22/23, D-x 1086 Berlin, DD 7 33
Hermetter, Albin c/o Technical University of Graz, Schlogelgasse 9, A-8010 Graz, AT 13 60
Langen, Peter c/o Academy of Sciences, Otto-Nuschke-Strasse 22/23, D-x 1086 Berlin, DD 8 73
Lehmann, Christine c/o Academy of Sciences, Otto-Nuschke-Strasse 22/23, D-x 1086 Berlin, DD 4 57
Matthes, Eckart c/o Academy of Sciences, Otto-Nuschke-Strasse 22/23, D-x 1086 Berlin, DD 8 125
Paltauf, Friedrich c/o Technical University of Graz, Schlogelgasse 9, A-8010 Graz, AT 8 58
Schildt, Jurgen c/o Academy of Sciences, Otto-Nuschke-Strasse 22/23, D-x 1086 Berlin, DD 1 9

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