Preparation of submicroscopic particles, particles thus obtained and pharmaceutical compositions containing them
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United States of America Patent
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Apr 3, 1990
Issued Date -
N/A
app pub date -
May 6, 1988
filing date -
Apr 24, 1981
priority date (Note) -
Expired
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Abstract
Process for the preparation of submicroscopic particles formed of a polymerized alkyl cyanoacrylate and containing a biologically active substance. At least one alkyl cyanoacrylate, in which the term 'alkyl' denotes an alkyl radical having 1 to 12 carbon atoms, is added, with stirring, to pure water or to an aqueous solution or aqueous colloidal solution of an acid and/or of another water-soluble substance, and the stirring is continued until substantially all the alkyl cyanoacrylate has been converted to submicroscopic particles formed of polyalkyl cyanoacrylate; a biologically active substance is introduced into the reaction medium before the introduction of the monomer or after formation of the submicroscopic particles. The submicroscopic particles are useful as carriers for substances such as medical substances or products for diagnosis.
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