Modified lipopolysaccharides and process of preparation
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United States of America Patent
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Mar 27, 1990
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N/A
app pub date -
Jun 29, 1988
filing date -
Jun 29, 1988
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Expired
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Abstract
Modified lipopolysaccharides, particularly de-3-0-acylated monophosphoryl lipid A and de-3-0-acylated diphosphoryl lipid A, are provided by an alkaline hydrolysis under controlled conditions which removes only the .beta.-hydroxymyristic acyl residue that is ester-linked to the reducing-end glucosamine at position 3. The modified products are less endotoxic and maintain their antigenic and immuno-stimulating properties.
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