Multidrug resistance in mammalian cell lines and isolation of determinant glycoprotein DNA

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United States of America Patent

PATENT NO 4912039
SERIAL NO

06774368

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Abstract

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A method for isolating a cDNA specific for P-glycoprotein is disclosed. The P-glycoprotein is the determinant in the multidrug resistance phenotype exhibited by living cells. The nucleic acid equivalent of the cDNA may be cloned in a recombinant plasmid or phage. The cDNA may also be used as a probe in determining multidrug resistance in cells. The DNA molecules specific for the P-glycoprotein is in the form of a gene family where various members of the gene family are amplified to varying degrees in multidrug resistant cells from various sources.

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Patent Owner(s)

Patent OwnerAddress
HSC RESEARCH DEVELOPMENT CORPOATON170 ELIZABETH STREET TORONTO ONTARIO M5G 1X8

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Riordan, John R Toronto, CA 10 102

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