Anxiolytic-n-(1-azabicyclo(2.2.2)oct-3-yl) benzamides and thiobenzamides
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United States of America Patent
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-
Mar 13, 1990
Grant Date -
N/A
app pub date -
Dec 15, 1987
filing date -
Dec 16, 1986
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Compounds of general formula I: ##STR1## wherein: X represents oxygen or sulphur; R.sup.1 represents loweralkyl; R.sup.2 represents hydrogen, halo, 4,5-benzo, loweralkoxy, amino, methylamino or dimethylamino; R.sup.3 represents hydrogen or loweralkyl; and n is 1 or 2 and their pharmaceutically acceptable acid addition salts have anxiolytic activity. In particular, they have activity against anxiety induced by the withdrawal from ingested substances such as narcotics (e.g. cocaine), alcohol and nicotine.
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