Novel process for the synthesis of amikacin
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United States of America Patent
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Feb 20, 1990
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N/A
app pub date -
Oct 2, 1986
filing date -
Oct 10, 1985
priority date (Note) -
Expired
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Abstract
A novel process for the synthesis of amikacin starting from kanamycin A protected at the positions 3 and 6' is described comprising the reaction of kanamycin A with a salt of a bivalent metal cation selected from zinc, nickel, iron, cobalt, manganese, copper and cadmium in the presence of water as the solvent or co-solvent followed by the in situ reaction of the resulting complex with a reactive derivative of L-amino-2-hydroxy-butyric acid, removal of the metal cation of the protecting groups and purification of the thus obtained raw product. The acylation under these conditions is extremely selective.
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