Non-radioactive carbodiimide precursor to nucleic acid probes
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United States of America Patent
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Jan 23, 1990
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N/A
app pub date -
May 27, 1988
filing date -
May 27, 1988
priority date (Note) -
Expired
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Abstract
This invention relates to carbodiimide compounds of the formula: Z--L--W--N.dbd.C.dbd.N--R.sub.1 wherein Z is a signalling moiety or a protecting group; L is a divalent linking group; W is an alkylene group having up to 24 carbon atoms which can be substituted or interrupted by a water solubility enhancing group or cleavable S--S group; and R.sub.1 is an alkyl group having up to 18 carbon atoms. These compounds are useful in the nonradioactive labelling of nucleic acid probes, and methods employing same.
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