In vivo delivery of neurotransmitters by implanted, encapsulated cells
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United States of America Patent
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Jan 9, 1990
Issued Date -
N/A
app pub date -
Nov 17, 1987
filing date -
Nov 17, 1987
priority date (Note) -
Expired
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Abstract
Methods and devices are disclosed for the delivery of a neurotransmitter from an implanted, neurotransmitter-secreting cell culture to a target region in a subject. The cell culture is maintained within a biocompatible, semipermeable membrane which permits the diffusion of the neurotransmitter therethrough while excluding viruses, antibodies, and other detrimental agents present in the external environment from gaining access. Implantable cell culture devices are disclosed, some of which may be retrieved from the subject, replaced or recharged with new, neurotransmitter-secreting cell cultures, and reimplanted.
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