Optical assay: method and apparatus
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United States of America Patent
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Oct 31, 1989
Grant Date -
N/A
app pub date -
Apr 4, 1986
filing date -
Apr 12, 1985
priority date (Note) -
Expired
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Abstract
An optical assay apparatus of the type comprising an optic waveguide and a coating sensitized to a specific assay species. The light signal response of the apparatus is enhanced by coupling a resonant metallic medium to the waveguide and to the sensitized coating. To this end, a metal coated transparent buffer layer may be interposed between the waveguide and the sensitized coating. Alternatively, a metallized optically matched grating can be used in place of the buffer layer or the metallic medium can be of particulate form, with each particle having a sensitized coating. In using the optical assay apparatus, the sensitized coating is exposed to a fluid assay sample. A light beam is directed onto the sensitized coating and reflected onto a detector. The detected light is monitored for any change indicating the presence of the specific assay species in the fluid sample.
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