Branched amides of L-aspartyl-D-amino acid dipeptides
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United States of America Patent
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Sep 26, 1989
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app pub date -
Oct 12, 1988
filing date -
Jan 21, 1980
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Expired
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Abstract
Amides of L-aspartyl-D-amino acid dipeptides of the formula ##STR1## and physiologically acceptable cationic and acid addition salts thereof wherein R.sup.a is methyl, hydroxymethyl, ethyl, n-propyl or isopropyl; R is ##STR2## where at least one of R.sup.3, R.sup.4, R.sup.5, R.sup.6 is alkyl having from one to four carbon atoms and the remainder are hydrogen or alkyl having from one to four carbon atoms, and the sum of the carbon atoms in R.sup.3, R.sup.4, R.sup.5 and R.sup.6 is not greater than six; and when both of R.sup.3 and R.sup.4 or R.sup.5 and R.sup.6 are alkyl, they are methyl or ethyl. Said amides are potent sweeteners having advantages over the prior art, edible compositions containing them, methods for their use in edible compositions and novel amine and amide intermediates useful in their production.
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