Process for the preparation of 2-alkoxy-N-(1-azabicyclo[2.2.2])octan-3-yl)aminobenzamides
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United States of America Patent
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Sep 26, 1989
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N/A
app pub date -
Feb 4, 1985
filing date -
Feb 4, 1985
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Expired
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Abstract
A process for the preparation of 2-alkoxy-N-(1-azabicyclo[2.2.2]octan-3-yl)aminobenzamides, which are gastric pharmaceuticals in monogastric animals having the formula: ##STR1## wherein R is hydrogen or loweralkyl, R.sup.1 is loweralkyl, R.sup.2 is hydrogen, halo or loweralkoxy, Am is amino, methylamino or dimethylamino is disclosed wherein in the initial step an appropriate monoprotonated 3-aminoquinuclidine strong acid salt and an appropriate amino benzoic acid all in a 50-90 vol. % pyridine in water solution are reacted in the presence of N,N'-dialkylcarbodiimide. The free base may be obtained by conventional procedures from the mixtures with minimal purification effort.
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