Derivatives of L-amino acyl L-carnitine, process for their preparation pharmaceutical compositions having hepatoprotecting activity containing same
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United States of America Patent
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Sep 19, 1989
Issued Date -
N/A
app pub date -
Nov 8, 1988
filing date -
Jul 2, 1986
priority date (Note) -
Expired
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Abstract
L-aminoacyl derivatives of L-carnitine of general formula (I) ##STR1## wherein R is an alkyl radical selected from 1-methyl-propyl, isobutyl, isopropyl, mercaptomethyl and 3-guanidino propyl, and their pharmacologically acceptable salts, are prepared e.g. by reacting a solution in an organic solvent of L-carnitine whose carboxyl group is protected with an N-protected aminoacid in the presence of a condensing agent and then removing the amino-acid and carnitine protecting groups, thus obtaining the desired compound.
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