Chemical capping by phosphitylation during oligonucleotide synthesis
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United States of America Patent
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Mar 28, 1989
Grant Date -
N/A
app pub date -
Jun 4, 1987
filing date -
Jun 4, 1987
priority date (Note) -
Expired
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Abstract
A method is provided for capping failure sequences in oligonucleotide synthesis by phosphitylation. A phosphite monoester is reacted with the 5' or 3' hydroxyl of the failure sequence between successive condensation steps in a synthesis procedure to form a 5' or 3' phosphite diester with the failure sequence. The phosphite diester substituent is inert with respect to subsequent reaction steps in the synthesis of the desired oligonucleotide product.
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