Method of inactivating reproductive filterable pathogens in fibrinogen and factor XIII compositions
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United States of America Patent
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Mar 28, 1989
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N/A
app pub date -
Sep 13, 1985
filing date -
Sep 28, 1984
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Expired
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Abstract
There is disclosed a method of inactivating reproductive filterable pathogens in tissue adhesives containing fibrinogen and Factor XIII, with their biologic activity being largely preserved. In order to provide a tissue adhesive preparation of human or animal origin, which exhibits a high safety with respect to reproductive filterable pathogens and whose biologic activity is largely preserved, preparations having a minimum content of 100 units of Factor XIII/g of fibrinogen are heated in the dry state in the presence of an oxygen-free inert protective gas or under vacuum.
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