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Abstract

Single-stage process for preparing mixed-substituted enantiomerically pure 1,2-diacyl-sn-glycero-3-phosphocholines of general formula I ##STR1## in which R.sub.1 and R.sub.2 are different and independently of each other denote a substituted or unsubstituted C.sub.1 to C.sub.24 -alkyl or C.sub.3 to C.sub.24 -alkenyl radical, by reacting 1-0-triphenylmethyl-2-acyl-sn-glycero-3-phosphocholine of the general formula ##STR2## in which T denotes a substituted or unsubstituted triphenylmethyl group and R.sub.2 is as defined above, with a reactive carboxylic acid derivative of the general formula R.sub.1 --CO--X III in which R.sub.1 is as defined above and X denotes a carboxylic acid radical, a carbonic acid radical, a sulfonic acid radical or the radical of a fused or unfused five-membered heterocycle having at least two N atoms in the ring, in the presence of a protonic acid, of a Lewis acid or of adducts thereof with electron donors, and isolating the resulting compounds of the general formula I from the reaction mixture.

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