1-(aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl)-.alpha.,.alpha.

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United States of America Patent

PATENT NO 4812451
SERIAL NO

06845148

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Abstract

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Novel 1-[(aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl-.alpha.,.alpha.-diaryl-pyrrolidine, piperidine and homopiperidineacetamides and acetonitriles having the formula: ##STR1## wherein; n is zero, one or two; X is oxygen or sulfur; Z is ##STR2## 10 or --(CH.sub.2); p is 0 to 5 inclusive with the proviso that when Z is ##STR3## p is at least one; Y is aminocarbonyl or cyano; Ar.sup.1 and Ar.sup.2 are 2, 3 or 4-pyrido, phenyl or substituted phenyl; R is hydrogen or loweralkyl; R.sup.1, R.sup.2 and R.sup.3 are hydrogen, cycloalkyl, loweralkyl, phenyl, substituted phenyl, phenylloweralkyl, and R.sup.2 and R.sup.3 taken with the adjacent nitrogen may form a heterocyclic residue, and diastereoisomers when possible and pharmaceutical salts; and the method and pharmaceutical compositions for treating cardiac arrhythmias therewith are disclosed.

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Patent Owner(s)

Patent OwnerAddress
A H ROBINS COMPANY INCORPORATED A DE CORPNot Provided

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Shanklin, Jr James R Richmond, VA 21 274
Wilkinson, II James M Richmond, VA 4 31

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