2-alkenylene-thieno-1,2-thiazole derivatives with lipid-lowering activity
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United States of America Patent
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Jan 31, 1989
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N/A
app pub date -
Jun 19, 1986
filing date -
Jul 4, 1985
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Expired
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Abstract
The invention relates to new thieno-1,2-thiazole derivatives of the formula ##STR1## wherein A, with the two carbon atoms of the thiazole ring, forms a group of the formula ##STR2## and the broken line indicates the double bond present in the thieno structures of the formulae IIa and IIb, n denotes the integer 2, 3 or 4, R denotes hydrogen or lower alkyl, R.sub.1 denotes hydrogen, lower alkyl, halogen, trifluoromethyl, lower alkoxy or lower alkylthio and R.sub.2 denotes hydrogen, lower alkyl or halogen; and the pharmaceutically acceptable salts of compounds of the formula I wherein R denotes hydrogen, a process for their preparation, pharmaceutical products containing these compounds, and their use in medicaments. The compounds of the formula I and salts thereof have a lipid-lowering action.
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