Process for the preparation of binder-free, tablettable granules of celiprolol hydrochloride
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United States of America Patent
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Jan 3, 1989
Grant Date -
N/A
app pub date -
Oct 21, 1987
filing date -
Oct 24, 1986
priority date (Note) -
Expired
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Abstract
Process for the preparation of binder-free granules which can be compressed to give solid medicament forms, which consists in initially placing a predetermined amount of celiprolol hydrochloride, over 50% of which have a particle size below 40 .mu.m and not more than 10% have a particle size above 100 .mu.m, in a fluidized bed granulator, forming a fluidized bed by passing in additional air at a temperature not higher than 30.degree. C. and, by spraying distilled water into the fluidized bed preparing free-flowing granules having a water content of 20-40% by weight, less than 10% of which have a particle size below 63 .mu.m, and drying these granules at temperatures from 30.degree. to 60.degree. C. after they have been discharged, and the use thereof.
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