Pentapeptides with cell growth regulatory effects and a process for the preparation thereof
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United States of America Patent
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Dec 27, 1988
Grant Date -
N/A
app pub date -
Feb 18, 1987
filing date -
Jun 26, 1985
priority date (Note) -
Expired
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Abstract
New pentapeptide of the formula ##STR1## in which X.sup.1 and X.sup.2 are the same or different and are OH or NH.sub.2, Y is H or OH, X.sup.3 is CO or CH.sub.2, one of the groups Z.sup.1 and Z.sup.2 is H and the other is H or CH.sub.3, all the amino acid unit being in L-configuration, with the exception that the C-terminal amino acid unit is in D-configuration when Z.sup.2 is methyl, and the C-terminal carboxyl group may be reduced to --CH.sub.2 --OH or be in amide form, and cation complexes and salts thereof. The pentapeptide may be prepared by subjecting a protected derivative thereof to deprotection. The pentapeptide has cell growth regulatory activity.
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