Crosslinked hemoglobin of extended shelf life and high oxygen transport capacity and process of preparing same
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United States of America Patent
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Oct 11, 1988
Issued Date -
N/A
app pub date -
May 8, 1987
filing date -
Nov 11, 1981
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Expired
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Abstract
Crosslinked hemoglobin preparations of extended shelf life and high oxygen transport capacity can be made by reducing a hemoglobin solution with an oxygen consuming reducing agent down to an oxygen partial pressure of 0 mbar, then adding an effector, crosslinking with a dialdehyde, reducing with a carbonyl-group-specific reducing agent, circulating through an ultrafilter, and stabilizing the product by adding a reducing agent thereto.
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