Peptide thioneamides as selective substrates for cysteine proteases
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United States of America Patent
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Sep 13, 1988
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N/A
app pub date -
Mar 11, 1986
filing date -
Mar 11, 1986
priority date (Note) -
Expired
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Abstract
Peptide thioneamides are provided as synthetic substrates for cysteine proteases. The compounds of the invention are peptides consisting of one or more blocked or unblocked amino acids wherein the terminal carboxy of the peptides are thionated and forms a thioneamide linkage with a fluorogenic or chromogenic leaving group. The alpha conbonyls of the remaining amino acids are thionated or unthionated. The invention includes methods and kits for using the peptide thioneamides.
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