Antracycline antineoplastic agents encapsulated in phospholipid vesicle particles and methods for using same for tumor therapy
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United States of America Patent
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Sep 6, 1988
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N/A
app pub date -
Oct 26, 1987
filing date -
Oct 15, 1985
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Expired
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Abstract
Formulations consisting of phospholipid bilayer membrane particles made from mixtures of anionic and neutral phospholipids encapsulating anthracycline anti-neoplastic agents, suspended in a low ionic strength aqueous phase, are described. In a preferred embodiment, the particles are in the form of vesicles which comprise daunorubicin, distearoyl phosphatidylglycerol and distearoyl phosphatidylcholine, the mol ratio of daunorubicin to distearoyl phosphatidylglycerol is at least about 1:1.25, and the suspending medium is an aqueous lactose solution containing a small amount of base.
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