Process for the preparation of a stable modification of torasemide
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United States of America Patent
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May 10, 1988
Grant Date -
N/A
app pub date -
Aug 11, 1986
filing date -
Aug 17, 1985
priority date (Note) -
Expired
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Abstract
The present invention provides a process for the preparation of crystalline torasemide in the pure modification I (monoclinic, space group P2.sub.1 /c, melting point 162.degree. C.) from torasemide of modification II (monoclinic, space group P2/n, melting point 169.degree. C.), wherein a suspension of torasemide of modification II is stirred in water with the addition of a catalytic amount of modification I until the rearrangement is complete. The present invention also provides a pharmaceutical compositions containing torasemide of modification I.
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