Method for enhancing and/or accelerating immunoassay detection of human carcinoma tumor associated antigen in a pathology sample
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United States of America Patent
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May 10, 1988
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N/A
app pub date -
Sep 9, 1985
filing date -
Sep 9, 1985
priority date (Note) -
Expired
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Abstract
Detection of an identified human carcinoma tumor antigen in a pathological sample by means of a labelled monoclonal antibody specific to the determinant site on the antigen is enhanced and/or accelerated at an earlier development stage than heretofore achieved by removing a carbohydrate steric hindrance for monoclonal antibody availability to bind the antigen of the tumor for which it is specific. The carbohydrate steric hindrance for monoclonal binding to the antigen is identified as sialic acid. The method of the invention involves selective removal of sialic acid from the antigen's determinant site by enzymatic digestion using neuraminidase.
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