Plasma fraction purification using silica resin bound to a ligand
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United States of America Patent
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Feb 16, 1988
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N/A
app pub date -
Aug 29, 1986
filing date -
Aug 29, 1986
priority date (Note) -
Expired
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Abstract
There is provided, in accordance with practice of this invention, a process for separating Factor IX and/or Factor X from an impure protein fraction containing protein in addition to Factors IX and X. A silica resin coupled with a ligand capable of binding Factor IX and/or Factor X is provided. An aqueous solution of the impure protein fraction is applied to the ligand-coupled silica resin to thereby bind the Factor IX and/or Factor X to the resin. The Factor IX and/or Factor X is then recovered from the resin by elution.
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