Importance

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Abstract

Compounds of formula I ##STR1## wherein, R.sub.1 represents hydrogen or methyl, R.sub.2 represents hydrogen or lower alkyl, lower alkenyl, lower alkynyl or cycloalkyl each of which may be unsubstituted or mono- or poly-substituted by amino, mono- or di(lower)-alkylamino, lower acylamino, carboxy, lower alkoxycarbonyl or carbamoyl; a group of formula IIc (CH.sub.2).sub.p --R.sub.5 IIc wherein R.sub.5 represents phenyl or a 5- or 6-membered saturated or unsaturated heterocycle containing one or more heteroatoms selected from O, S and/or N and which may be unsubstituted or mono- or poly-substituted by fluoro, chloro, bromo, amino, mono- or di-(lower)-alkylamino, hydroxy, lower alkoxy, mercapto, alkylthio, phenylthio, sulfamoyl, guanidino, nitro, cyano, lower acylamino, carboxy, alkoxycarbonyl or carbamoyl and p is 0, 1, 2 or 3; or a group of formula ##STR2## wherein R.sub.6, R.sub.7 and R.sub.8 may be the same or different and each represents hydrogen or lower alkyl or R.sub.6 and R.sub.8 and/or R.sub.7 and one of the CH.sub.2 groups may be joined to form a ring as may R.sub.7 and R.sub.8 in formula II and R.sub.6 and R.sub.7 in IIa and IIb, which rings may be unsubstituted or mono- or poly-substituted by alkyl, hydroxy, carboxy or di-(lower)-alkyl-amino, m is 2 or 3, and n is 1, 2 or 3 R.sub.3 represents hydrogen or lower alkyl and R.sub.4 represents lower alkyl, which are indicated for use as pharmaceuticals particularly as antibacterially active antibiotics.

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First Claim