Renin inhibitors and treatments using them
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United States of America Patent
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Dec 15, 1987
Issued Date -
N/A
app pub date -
Aug 17, 1984
filing date -
Aug 19, 1983
priority date (Note) -
Expired
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Abstract
Renin-inhibiting analogues of formula ##STR1## where X and W are terminal groups optionally with further amino acyl residues; D, E, B and Z (of which any one or except with `reduced` analogues any two may be absent) are aromatic, lipophilic or in the case of E aromatic lipophilic or basic amino acid or amino acid analogue residues; and A is an analogue of a lipophilic or aromatic dipeptide residue wherein the peptide link is replaced by a one- to four-atom carbon or carbon-nitrogen link which as such or in hydrated form is an unhydrolysable tetrahedral analogue of the transition state ##STR2## of peptide bond hydrolysis.
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