2-chloropentostatin compound having adenosine diaminase inhibitory activity
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United States of America Patent
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Dec 15, 1987
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N/A
app pub date -
Nov 8, 1985
filing date -
Mar 16, 1984
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Abstract
2'-Chloropentostatin is a potent inhibitor of the enzyme adenosine deaminase and possesses utility as an agent for potentiating the activity of antiviral agents for the treatment of DNA viruses which agents contain an adenine moiety, such as 9-(beta-D-arabinosyl)adenine. A pure strain of actinomycete, designated ATCC 39365 which is capable of producing 2'-chloropentostatin, a method of producing 2'-chloropentostatin by aerobic fermentation, and pharmaceutical compositions including 2'-chloropentostatin are also disclosed.
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