Isoquinolinesulfonamide derivatives

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United States of America Patent

PATENT NO 4709032
SERIAL NO

06919774

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Abstract

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This invention relates to novel isoquinolinesulfonamide derivatives of Formula (I): ##STR1## wherein A is a C.sub.0-10 alkylene group or a C.sub.0-10 alkylene group having a C.sub.1-10 alkyl group, a phenyl group, a substituted phenyl group or a phenylalkyl group; R.sub.1 and R.sub.2 each is a hydrogen atom; or R.sub.1 and R.sub.2 are linked directly to form an ethylene group unsubstituted or substituted with a C.sub.1-4 alkyl group; R.sub.3 and R.sub.4 each is a hydrogen atom, a C.sub.1-6 alkyl group or linked directly to form a C.sub.2-6 alkylene group; and the pharmaceutically acceptable acid addition salt thereof, and to a process for preparing them. The isoquinoline derivatives possess a relaxatory action for vascular smooth muscle and action for increasing blood flow and are useful as a vasodilator and a hypotensor.

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Patent Owner(s)

Patent OwnerAddress
ASAHI KASEI KOGYO KABUSHIKI KAISHA2-6 DOJIMAHAMA 1-CHOME KITA-KU OSAKA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hidaka, Hiroyoshi Tsu, JP 27 369
Sone, Takanori Nobeoka, JP 25 457

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