Allosteric conjugates of hemoglobin and use as blood substitutes
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United States of America Patent
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Oct 6, 1987
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N/A
app pub date -
Oct 26, 1984
filing date -
Nov 10, 1983
priority date (Note) -
Expired
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Abstract
The invention relates to an allosterically active conjugate composition comprising one or more hemoglobin tetramers and one or more adducts of a physiologically safe macromolecular agent covalently linked to one or more ligands, such that the adduct is bound to the allosteric binding site of the hemoglobin in a reversible, non-covalent manner; the invention also relates to methods for producing such conjugate compositions; and to blood substitutes or plasma extenders containing such conjugates.
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