Novel physiologically active substance MH435

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United States of America Patent

PATENT NO 4686308
SERIAL NO

06879069

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Disclosed is a novel physiologically active substance, MH435, represented by the formula: ##STR1## wherein R represents either of the following groups A and B A: --CH.dbd.CH--NHCHO B: --CH.sub.2 --CH.sub.2 --NHCHO. The substance MH435 has an inhibitory activity against tyrosine specific protein kinase, and the 50% inhibitory concentrations of the substances MH435-A and MH435-B are respectively 0.55 .mu.g/ml and 6.0 .mu.g/ml.

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Patent Owner(s)

Patent OwnerAddress
MICROBIAL CHEMISTRY RESEARCH FOUNDATIONTOKYO 141-0021

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hamada, Masa Tokyo, JP 39 228
Iinuma, Hironobu Wako, JP 13 76
Imoto, Masaya Urawa, JP 7 17
Isshiki, Kunio Fujisawa, JP 16 24
Naganawa, Hiroshi Tokyo, JP 34 385
Sawa, Tsutomu Ayase, JP 26 226
Takeuchi, Tomio Tokyo, JP 164 840
Uchida, Takeshi Takasaki, JP 122 741
Umezawa, Hamao Tokyo, JP 141 779

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