Erythro-(E)-7-[3'-C.sub.1-3 alkyl-1'-(3",5"-dimethylphenyl)naphth-2'-yl]-3,5-dihydroxyhept-6-enoic acids and derivatives thereof
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United States of America Patent
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Aug 11, 1987
Issued Date -
N/A
app pub date -
Feb 19, 1986
filing date -
Jul 24, 1984
priority date (Note) -
Expired
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Abstract
Compounds of the formula ##STR1## wherein R.sub.1 is C.sub.1-3 alkyl, and Z is ##STR2## wherein R.sub.7 is hydrogen, R.sub.8 or M, wherein R.sub.8 is a physiologically acceptable and hydrolyzable ester group, and M is a pharmaceutically acceptable cation, the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis, pharmaceutical compositions comprising such compounds and processes for and intermediates in the synthesis of such compounds.
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